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Optical Biosensing of Gaseous Nitric Oxide Using Spin-Coated Sol−Gel Thin Films

1997; American Chemical Society; Volume: 9; Issue: 11 Linguagem: Inglês

10.1021/cm970324v

1520-5002

Jonathan W. Aylott, David J. Richardson, David A. Russell,

Electrochemical sensors and biosensors

The development of a spin-coating technique for the formation of sol−gel films, of micrometer thickness, containing encapsulated cytochrome c for the optical biosensing of gaseous NO is reported. The optical biosensing system has been characterized in terms of reproducibility, reversibility, response time, and specificity for the target analyte. While NO2 gas does interfere with the sensor response, it is thought that the reported method of spin-coated sol−gel thin films could be applied to other, more specific, biorecognition elements for gaseous analyte detection.