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Bioactive Principles from the Roots of Lindera megaphylla

1991; Thieme Medical Publishers (Germany); Volume: 57; Issue: 05 Linguagem: Inglês

10.1055/s-2006-960135

1439-0221

C. Chen, Yi‐Fang Huang, Jingxing Ou, Ming‐Jai Su, Sung‐Liang Yu, Che‐Ming Teng,

Phytochemistry and biological activities of Ficus species

d-Dicentrine was isolated from the root of Lindera megaphylla. It inhibited the aggregation of washed rabbit platelets induced by ADP, collagen, arachidonic acid, and PAF. It also inhibited the high potassium- and norepinephrine-induced contraction of rat thoracic aorta. In rat ventricular cells treated with 3 µM d-dicentrine, the action potential duration (ADP50) was prolonged from 59.9 ± 11.3 msec to 201 ± 28.7 msec.