Orally administered polypodium leucotomos extract decreases psoralen-UVA–induced phototoxicity, pigmentation, and damage of human skin
2003; Elsevier BV; Volume: 50; Issue: 1 Linguagem: Inglês
10.1016/s0190-9622(03)02732-4
ISSN1097-6787
AutoresMaritza A. Middelkamp‐Hup, Madhu A. Pathak, Concepción Parrado, Tomás García‐Caballero, Francisca Ríus, Thomas B. Fitzpatrick, Salvador González,
Tópico(s)Psoriasis: Treatment and Pathogenesis
ResumoBackground The use of psoralen-UVA (PUVA) in patients of skin phototype I to II is limited by side effects of acute phototoxicity and possible long-term carcinogenesis. Objective We sought to assess oral Polypodium leucotomos (PL) extract in decreasing PUVA-induced phototoxicity of human skin on a clinical and histologic level. Methods A total of 10 healthy patients with skin phototypes II to III were exposed to PUVA alone (using 0.6 mg/kg oral 8-methoxypsoralen) and to PUVA with 7.5 mg/kg of oral PL. Results Clinically, phototoxicity was always lower in PL-treated skin after 48 to 72 hours (P < .005), and pigmentation was also reduced 4 months later. Histologically, PL-treated skin showed a significant numeric reduction of sunburn cells (P = .05), preservation of Langerhans cells (P ≤ .01), decrease of tryptase-positive mast cell infiltration (P < .05), and decrease of vasodilation (P ≤ .01). No differences were found in Ki-67+ proliferating cells. Conclusions PL is an effective chemophotoprotector against PUVA-induced skin phototoxicity and leads to substantial benefits of skin protection against damaging effects of PUVA as evidenced by histology.
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