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NEUROPHYSIOLOGICALLY-BASED MEAN-FIELD MODELLING OF TONIC CORTICAL ACTIVITY IN POST-TRAUMATIC STRESS DISORDER (PTSD), SCHIZOPHRENIA, FIRST EPISODE SCHIZOPHRENIA AND ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)

2004; Imperial College Press; Volume: 03; Issue: 04 Linguagem: Inglês

10.1142/s0219635204000592

1757-448X

DONALD L. ROWE, P. A. Robinson, Christopher Rennie, Anthony Harris, Kim L. Felmingham, Ilario Lazzaro, Evian Gordon,

Neural dynamics and brain function

Journal of Integrative NeuroscienceVol. 03, No. 04, pp. 453-487 (2004) Research ReportsNo AccessNEUROPHYSIOLOGICALLY-BASED MEAN-FIELD MODELLING OF TONIC CORTICAL ACTIVITY IN POST-TRAUMATIC STRESS DISORDER (PTSD), SCHIZOPHRENIA, FIRST EPISODE SCHIZOPHRENIA AND ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)DONALD L. ROWE, PETER A. ROBINSON, CHRISTOPHER J. RENNIE, ANTHONY W. HARRIS, KIM L. FELMINGHAM, ILARIO L. LAZZARO, and EVIAN GORDONDONALD L. ROWESchool of Physics, University of Sydney, NSW 2006, Australia The Brain Dynamics Centre and Department of Psychological Medicine, Westmead Hospital and University of Sydney, NSW 2145, Australia Search for more papers by this author , PETER A. ROBINSONSchool of Physics, University of Sydney, NSW 2006, AustraliaThe Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW 2145, Australia Search for more papers by this author , CHRISTOPHER J. RENNIESchool of Physics, University of Sydney, NSW 2006, AustraliaThe Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW 2145, Australia Search for more papers by this author , ANTHONY W. HARRISThe Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW 2145, Australia Search for more papers by this author , KIM L. FELMINGHAMThe Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW 2145, Australia Search for more papers by this author , ILARIO L. LAZZAROThe Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW 2145, Australia Search for more papers by this author , and EVIAN GORDONThe Brain Dynamics Centre, Westmead Hospital and University of Sydney, NSW 2145, AustraliaThe Brain Resource Company, Sydney, NSW 2007, Australia Search for more papers by this author https://doi.org/10.1142/S0219635204000592Cited by:20 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractA recently developed quantitative model of cortical activity is used that permits data comparison with experiment using a quantitative and standardized means. The model incorporates properties of neurophysiology including axonal transmission delays, synapto-dendritic rates, range-dependent connectivities, excitatory and inhibitory neural populations, and intrathalamic, intracortical, corticocortical and corticothalamic pathways. This study tests the ability of the model to determine unique physiological properties in a number of different data sets varying in mean age and pathology. The model is used to fit individual electroencephalographic (EEG) spectra from post-traumatic stress disorder (PTSD), schizophrenia, first episode schizophrenia (FESz), attention deficit hyperactivity disorder (ADHD), and their age/sex matched controls. The results demonstrate that the model is able to distinguish each group in terms of a unique cluster of abnormal parameter deviations. The abnormal physiology inferred from these parameters is also consistent with known theoretical and experimental findings from each disorder. The model is also found to be sensitive to the effects of medication in the schizophrenia and FESz group, further supporting the validity of the model.Keywords:Thalamocorticalthalamic reticular nucleusarousalneuronpruningsynapseEEG References F. Amzica and M. Steriade, Electroen. Clin. Neuro. 107, 69 (1998). 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