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DDAVP‐induced increases in coagulation factor VIII and von Willebrand factor in the plasma of conscious dogs

1986; Wiley; Volume: 9; Issue: 4 Linguagem: Inglês

10.1111/j.1365-2885.1986.tb00057.x

1365-2885

Gary S. Johnson, K. Kraus, Mark Turrentine, P Dean,

Platelet Disorders and Treatments

Johnson, G.S., Kraus, K.H., Turrentine, M.A. & Dean P.W. DDAVP‐induced increases in coagulation factor VIII and von Willebrand factor in the plasma of conscious dogs. J. vet. Pharmacol. Therap. 9, 370–375. Infusion of the vasopressin analogue DDAVP into five normal dogs at doses of 0.1–2.0 ng DDAVP per kg body weight induced dose‐dependent increases in the plasma content of coagulation factor VIII and von Willebrand factor. Plasma concentrations of von Willebrand factor (determined antigenically as factor VHI‐related antigen and functionally as coagglutinin cofactor activity) and coagulation factor VIII were measured immediately before and at 10, 30, and 120 min after 10‐min intravenous infusions of DDAVP. The greatest increases in coagulation factor VIII were produced with the 2.0 μg/kg dose. Ten minutes after infusion the mean increase in coagulation factor VIII was 32 units/dl (concentrations of all indices were reported relative to concentrations in a standard canine plasma pool, arbitrarily assigned a concentration of 100 units/dl) and this increase did not change significantly throughout the duration of the experiment. At 10 min post‐infusion, the mean factor VHI‐related antigen concentration increased 81 units/dl (dose = 2.0 μg/kg) and did not change significantly for the duration of the experiment. The maximum mean increase in coagglutinin cofactor activity, 141 units/dl, occurred 10 min after infusion (dose = 1.0 μg/kg). Coagglutinin cofactor activity decreased significantly from peak activity by 120 min post‐infusion