Inhibition of rubral neurons by a specific ligand for σ receptors
1988; Elsevier BV; Volume: 158; Issue: 1-2 Linguagem: Inglês
10.1016/0014-2999(88)90268-3
ISSN1879-0712
AutoresRae R. Matsumoto, James M. Walker,
Tópico(s)Axial and Atropisomeric Chirality Synthesis
Resumo1,3-Di-ortho-tolylguanidine (DTG), a compound with marked selectivity for σ receptors was iontophoretically applied to neurons in the red nucleus and nearby mesencephalic reticular formation. Spontaneous firing of rubral neurons was reduced by DTG in most cases. However, in the reticular formation, less than half of the cells tested showed inhinition; the remaining cells showed either an increase in rate or no consistent response to DTG. This corresponds to the greater density of σ receptors in the red nucleus and supports previous work which suggests that σ receptors play a role in the regulation of movement and posture.
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