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The effect of chondroitin sulfate on bone healing

1965; Elsevier BV; Volume: 20; Issue: 6 Linguagem: Inglês

10.1016/0030-4220(65)90143-x

1878-2175

Martin Moss, Gustav O. Kruger, D. C. Reynolds,

Osteoarthritis Treatment and Mechanisms

1. A series of mongrel dogs were subjected to bilateral surgical extraction of maxillary cuspids. A gelatin sponge impregnated with a solution of chondroitin sulfate was implanted in one socket, and a saline-impregnated sponge was implanted in the control socket. The animals were killed at postoperative intervals of 2 to 16 weeks. 2. Within 2 weeks all sockets were completely filled with connective tissue. The experimental sockets contained a greater amount of dense cellular tissue, usually associated with osteogenesis, than the control sockets. 3. After 4 and 6 weeks the experimental sockets had more young bone growth than the controls. This was most pronounced at 4 weeks. 4. After 8 weeks no difference in the bony repair was evident between the experimental and control sockets. 5. Chondroitin sulfate appeared to accelerate the rate of bony repair but did not affect the ultimate quantity or quality of bone produced.