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Identification of labeled thyroxine and triiodothyronine in amphioxus treated with 131I

1962; Elsevier BV; Volume: 56; Linguagem: Inglês

10.1016/0006-3002(62)90570-x

1878-2434

Winton Tong, P.R. Kerkof, I.L. Chaikoff,

Thyroid Disorders and Treatments

Specimens of the protochordate, amphioxus, were maintained in sea water containing 131I for periods rainging from I h to II days. The utilization of the 131I was studied with the aid of paper-chromatographic techniques. The highest concentration of 131I was found in the endostylar region of these animals, but 131I protein was also found in the notochord, the hepatic cecum, and carcass tissues. 131Ithyroxine and [131I]triiodothyronine were found in this thyroidless organism and clearly identified by co-chromatography with authentic compounds. In contrast to observations made in mammalian thyroid glands, [131I]triiodothyronine was formed in proportions equal to ar greater than those of [131I]thyroxine.