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TAp73 Acts via the bHLH Hey2 to Promote Long-Term Maintenance of Neural Precursors

2010; Elsevier BV; Volume: 20; Issue: 22 Linguagem: Inglês

10.1016/j.cub.2010.10.029

1879-0445

Masashi Fujitani, Gonzalo I. Cancino, Sagar B. Dugani, Ian C.G. Weaver, Andrée Gauthier-Fisher, Annie Paquin, Tak W. Mak, Martin J. Wojtowicz, Freda D. Miller, David R. Kaplan,

Cancer-related Molecular Pathways

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These findings, and the link between the p53 family, stem cells, and aging, suggest that TAp73 might play a previously unanticipated role in maintenance of neural stem cells. Here, we have tested this hypothesis and show that TAp73 ensures normal adult neurogenesis by promoting the long-term maintenance of neural stem cells. Moreover, we show that TAp73 does this by transcriptionally regulating the bHLH Hey2, which itself promotes neural precursor maintenance by preventing premature differentiation.