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Diuretic and natriuretic effects of chromatographically purified fraction of garlic (Allium sativum)

1996; Elsevier BV; Volume: 52; Issue: 2 Linguagem: Inglês

10.1016/0378-8741(96)01396-7

1872-7573

C. Pantoja, Beryl Norris, Cecilia Contreras,

Pregnancy and Medication Impact

The intravenous administration of chromatographically purified fractions of garlic (2, 4 and 6 μg/kg dry weight) to anaesthetized rabbits elicits dose-dependent diuretic-natriuretic responses which reach a maximum 60 min after injection, and return to basal levels after 90 min. A gradual decrease in heart rate, but not in arterial blood pressure was observed during the course of the experimental periods. The electrocardiogram was not affected.