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Ovine Corticotropin-Releasing Hormone Stimulation Test in Normal Children

1986; Oxford University Press; Volume: 62; Issue: 2 Linguagem: Inglês

10.1210/jcem-62-2-390

1945-7197

Judith L. Ross, Heinrich M. Schulte, William T. Gallucci, Gordon B. Cutler, D. Lynn Loriaux, George P. Chrousos,

Growth Hormone and Insulin-like Growth Factors

We administered ovine corticotropin-releasing hormone (CRH) as a bolus iv injection (1 microgram/kg) to 21 normal boys and girls, aged 6-15 yr. CRH stimulated release of immunoreactive ACTH and cortisol in all children. The peak plasma ACTH and cortisol levels after CRH were 15.7 +/- 9.4 (SD) pg/ml and 14.3 +/- 3.6 micrograms/dl, respectively, in the girls, and 20.7 +/- 9.7 pg/ml and 16.6 +/- 3.3 micrograms/dl, respectively, in the boys. Plasma ACTH and cortisol responsiveness to CRH did not differ between girls or boys, or between children and adults. Cortisol-binding globulin concentrations in plasma did not change with age. We conclude that CRH provides a safe means of stimulating the pituitary-adrenal axis in children.