Study on DNA damage induced by CdSe quantum dots using nucleic acid molecular “light switches” as probe
2006; Elsevier BV; Volume: 71; Issue: 4 Linguagem: Inglês
10.1016/j.talanta.2006.07.048
ISSN1873-3573
AutoresJiangong Liang, Zhike He, Shusheng Zhang, Shan Huang, Xinping Ai, Hanxi Yang, Heyou Han,
Tópico(s)Gold and Silver Nanoparticles Synthesis and Applications
ResumoThe calf thymus DNA (ctDNA) damage induced by water-soluble CdSe quantum dots (QDs) was investigated using nucleic acid molecular "light switches" as probe. It was found that little ctDNA was damaged by CdSe QDs without UV irradiation. However, under UV irradiation, ctDNA was nicked by CdSe QDs very clearly. The mechanism of ctDNA damage was also discussed. The results strongly suggested that the ctDNA damage caused by CdSe QDs was not due to photo-induced liberation of Cd2+, but due to the production of free radicals and reactive oxygen species.
Referência(s)