Synthesis and antitumour activity of derivatives of curdlan and lichenan branched at C-6
1992; Elsevier BV; Volume: 226; Issue: 2 Linguagem: Inglês
10.1016/0008-6215(92)84071-y
ISSN1873-426X
AutoresSabine Demleitner, J. Kraus, Gerhard Franz,
Tópico(s)Polysaccharides Composition and Applications
ResumoDerivatives of curdlan and lichenan, linear (1→3)-β-d- and (1→3/1→4)-β-d-glucans, respectively, have been synthesised having α-l-arabinofuranosyl, α-l-rhamnosyl, β-d-glucosyl, and β-gentiobiosyl side chains attached at positions 6. These water-soluble derivatives, obtained by condensation of the 2,4- and 2,4/2,3-di-O-phenylcarbamoyl derivatives of curdlan and lichenan, respectively, with appropriate ortho esters followed by saponification, were characterised by methylation analysis, g.p.c., and interaction with Congo Red. The curdlan derivatives and the lichenan derivative with few glucosyl branches were active against the Sarcoma 180.
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