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Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: Synthesis, structure, spectroscopy, and biological activity

2005; Elsevier BV; Volume: 99; Issue: 7 Linguagem: Inglês

10.1016/j.jinorgbio.2005.04.012

1873-3344

Zahra Afrasiabi, Ekk Sinn, Weisheng Lin, Yinfa Ma, Charles F. Campana, Subhash Padhyé,

Synthesis and biological activity

Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. The X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue.