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Differential effects of nicotine but not cathinone on motor activity of P and NP rats

1993; Elsevier BV; Volume: 44; Issue: 3 Linguagem: Inglês

10.1016/0091-3057(93)90182-s

1873-5177

Timothy L. Gordon, Susanne M. Meehan, Martin D. Schechter,

Neuroscience and Neuropharmacology Research

The locomotor stimulatory effects of nicotine (0.4 and 0.8 mg/kg) and cathinone (0.5 and 1.0 mg/kg) were assessed in alcohol-preferring (P) and -nonpreferring (NP) rats. Whereas P rats demonstrated enhanced (0.8 mg/kg) or no change (0.4 mg/kg) in spontaneous locomotor activity (SMA) to nicotine, NP animals showed no change (0.4 mg/kg) or depression of activity (0.8 mg/kg). However, following cathinone administration both P and NP rats exhibited an increase in SMA. The above results are discussed in light of the genotypic variations between P/NP rats and the potential mediation of differential neurotransmitter effects in the two lines.