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Effect of isoproterenol on blood pressure, plasma renin activity, and water intake in rats

1974; Elsevier BV; Volume: 26; Issue: 2 Linguagem: Inglês

10.1016/0014-2999(74)90218-0

1879-0712

Frans H. H. Leenen, Robert H. McDonald,

Renin-Angiotensin System Studies

The effects of s.c. administered isoproterenol on blood pressure, plasma renin activity and water intake were studied in unanaesthetized rats as a function of both concentration and time. Isoproterenol (1, 10, 100 and 500 μg/kg) induced a rapid, dose-related decrease in blood pressure and increase in plasma renin activity. Both parameters were found to be nearly normal after 60 min, except after the highest dose. Isoproterenol (⪖ 10 μg/kg) caused a dose-dependent increase in water intake; after the highest dose 5–6 mlH2O/100 g b.w. was ingested within 60 min. In rats on a sodium-deficient diet, the effect of isoproterenol on renin release and water intake was potentiated whereas in DOCA-pretreated rats, the effect was inhibited. The different actions of isoproterenol, 100 μg/kg were blocked by propranolol, partly (0.5 mg/kg) or completely (2.5 and 10 mg/kg). The results indicate that the action of isoproterenol on water intake is correlated with its ability to induce renin release.