Euphoportlandols A and B, Tetracylic Diterpene Polyesters from Euphorbia p ortlandica and Their Anti-MDR Effects in Cancer Cells
2006; American Chemical Society; Volume: 69; Issue: 6 Linguagem: Inglês
10.1021/np060046r
ISSN1520-6025
AutoresAM Madureira, Nóra Gyémánt, José R. Ascenso, Pedro Abreu, Joséph Molnár, Maria‐José U. Ferreira,
Tópico(s)Phytochemistry and Biological Activities
ResumoTwo new tetracyclic diterpene polyesters, euphoportlandols A (1) and B (2), have been isolated along with 12 known tetracyclic triterpenes from an acetone extract of Euphorbia portlandica. Their structures were established as 5α,11α,14α,17-tetraacetoxy-3β-benzoyloxy-6β,15β-dihydroxy-9-oxoseget-8(12)-ene (1) and 5α,11α,14α,17-tetraacetoxy-3β-benzoyloxy-6β,15β-dihydroxy-9-oxosegetane (2), respectively, by spectroscopic data interpretation. Compounds 1 and 2 were evaluated for their ability to inhibit multidrug resistance in cancer cells. Both compounds were found to be inhibitors of P-glycoprotein activity.
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