Prodrugs of phosphates, phosphonates, and phosphinates
1996; Elsevier BV; Volume: 19; Issue: 2 Linguagem: Inglês
10.1016/0169-409x(95)00111-j
ISSN1872-8294
AutoresJeffrey P. Krise, Valentino J. Stella,
Tópico(s)Pneumocystis jirovecii pneumonia detection and treatment
ResumoThe objective of this paper is to review the literature on the use of prodrugs to overcome the drug delivery obstacles associated with phosphate, phosphonate and phosphinate functional group-containing drugs. This is an important area of research because, although we have been successful at identifying numerous phosphate and phosphonate functional group-containing drugs as antiviral and anticancer agents, as well as for other uses, our ability to orally deliver these drugs and to target them to desired sites has led to limited success. Various acyloxymethyl- and aryl-ester prodrugs have shown promise. Alternative and imaginative approaches may be necessary before complete success is realized. It is our hope that this review will stimulate further innovative prodrug research into overcoming the barriers to the delivery of these important drugs.
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