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Chalcone based aryloxypropanolamines as potential antihyperglycemic agents

2006; Elsevier BV; Volume: 17; Issue: 3 Linguagem: Inglês

10.1016/j.bmcl.2006.10.068

1464-3405

Poonam Shukla, Amar Singh, Arvind K. Srivastava, Ram Pratap,

Quinazolinone synthesis and applications

A series of chalcone based aryloxypropanolamines were synthesized and evaluated for their antihyperglycemic activity in SLM and STZ rat models. Most of the compounds exhibited moderate to good activity ranging from 6.5% to 31.1% in SLM and 8.3% to 22.6% in STZ models, respectively. The most potent compound 5g exhibited glucose lowering of 26.7% in SLM and 22.6% in STZ models. A definite structure–activity relationship was observed while varying the nature as well as the position of the amine in ring B.