Design of a new class of chiral C 2 -symmetric dipyridylmethane ligands and their application in asymmetric catalysis
2002; Elsevier BV; Volume: 43; Issue: 47 Linguagem: Inglês
10.1016/s0040-4039(02)02066-x
ISSN1873-3581
AutoresGiorgio Chelucci, Giovanni Loriga, Gabriele Murineddu, Gérard A. Pinna,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoA new class of chiral C2-symmetric dipyridylmethane ligands was prepared from naturally occurring monoterpenes, according to a method based on a double Michael–azaannellation–aromatization sequence. These ligands were assessed in the enantioselective palladium-catalyzed allylic alkylation of 1,3-diphenylprop-2-enyl acetate with dimethylmalonate and in the copper-catalyzed cyclopropanation of styrene with ethyl diazoacetate. Enantioselectivity up to 88% ee was obtained.
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