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Proteinuria following Trauma

1986; SAGE Publishing; Volume: 23; Issue: 6 Linguagem: Inglês

10.1177/000456328602300610

1758-1001

Peter Gosling, Anne J. Sutcliffe,

Trauma, Hemostasis, Coagulopathy, Resuscitation

Thirteen trauma patients admitted to a major injuries unit were classified according to their injury severity. Urinary excretion of total protein, albumin and gamma glutamyl transpeptidase (GGT) activity were assessed over the following 6 days. All patients showed an initial glomerular and tubular proteinuria during the first 24 h which subsided by the second post-trauma day. The excretion of total protein and albumin was positively correlated with injury severity. Those patients with the severest injuries showed a marked recurrent total proteinuria around days 3 to 4 post-trauma which exhibited features of a tubular lesion. The recurrent proteinuria peak coincided with peak levels of serum c-reactive protein (CRP).