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Synthesis and Herbicidal Activity of N -Oxide Derivatives

2000; American Chemical Society; Volume: 48; Issue: 7 Linguagem: Inglês

10.1021/jf9904766

1520-5118

Hugo Cerecetto, Eduardo Días, Rossanna Di Maio, Mercedes González, Sandra Pacce, Patricia Saenz‐Méndez, Gustavo Seoane, Leopoldo Suescun, Álvaro W. Mombrú, Grisel Fernández, Marisa Lema, Juana Villalba,

Analytical Chemistry and Chromatography

As part of an ongoing program on the chemistry and biological activity of N-oxide-containing molecules, a number of novel 1,2,5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline N,N'-dioxide derivatives were synthesized and evaluated for their herbicidal activity. Many of these compounds exhibited moderate to good herbicidal pre-emergence activity against Triticum aestivum. Dose−response studies were done on the more representative compounds (12, 20, and 26). The most active compound, butylcarbamoylbenzo[1,2-c]1,2,5-oxadiazole N-oxide, 26, displayed herbicidal activity at concentrations as low as 24 g/ha. Keywords: Herbicide; 1,2,5-oxadiazole N-oxide; benzo[1,2-c]1,2,5-oxadiazole N-oxide; quinoxaline N,N'-dioxide