Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome
2010; Elsevier BV; Volume: 41; Issue: 3 Linguagem: Inglês
10.1016/j.nbd.2010.11.011
ISSN1095-953X
AutoresJeong Seon Yoon, Jong‐Hwan Lee, Tae Gen Son, Mohamed R. Mughal, Nigel H. Greig, Mark P. Mattson,
Tópico(s)Neuroinflammation and Neurodegeneration Mechanisms
ResumoPregabalin, a Ca2+ channel α2δ-subunit antagonist with analgesic and antiepileptic activity, reduced neuronal loss and improved functional outcome in a mouse model of focal ischemic stroke. Pregabalin administration (5–10 mg/kg, i.p.) 30–90 min after transient middle cerebral artery occlusion/reperfusion reduced infarct volume, neuronal death in the ischemic penumbra and neurological deficits at 24 h post-stroke. Pregabalin significantly decreased the amount of Ca2+/calpain-mediated α-spectrin proteolysis in the cerebral cortex measured at 6 h post-stroke. Together with the extensive clinical experience with pregabalin for other neurological indications, our findings suggest the potential for a therapeutic benefit of pregabalin in stroke patients.
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