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Influence of Asphyxia on Membrane Potential Level and Action Potentials of Spinal Moto‐ and Interneurons

1959; Wiley; Volume: 45; Issue: 1 Linguagem: Inglês

10.1111/j.1748-1716.1959.tb01673.x

1365-201X

G Kolmodin, C. R. Skoglund,

Ion channel regulation and function

Abstract K olmodin , G. M. and C. R. S koglund . Influence of asphyxia on membrane potential level and action potentials of spinal moto‐ and interneurons. Acta physiol. scand . 1959. 45 . 1–18. — Asphyxial changes in spinal moto‐ and interneurons of decapitate cats were studied by means of intracellular microelectrodes. In both types of neurons the first change in membrane potential was usually observed after about 30 sec in the form of a depolarization of 5–10 mV which after some 30 sec was followed by a phase of more rapidly developing depolarization of larger amplitude; during recovery a phase of increased polarization may be observed. Interneurons showed signs of being more resistant to asphyxia than moto‐neurons. The spib potential underwent a. successive diminution in amplitude, at first owing to the decrease in membrane potential value, later also due to a change in spike peak level. During the later stage of asphyxia a decrease of both the rate of rise of the ascending and the rate of decay of the descending spike phases could be demonstrated. Rhythmical interneuron discharges showed periods of increased and decreased frequency before final blocking.