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Airways Remodelling in Asthma: No Doubt, No More?

1995; Karger Publishers; Volume: 107; Issue: 1-3 Linguagem: Inglês

10.1159/000236980

1423-0097

Jean Bousquet, Antonio M. Vignola, Pascal Chanez, Alison Campbell, G Bonsignore, F. B. Michel,

Inhalation and Respiratory Drug Delivery

Asthma is a chronic inflammatory disease of the airways invariably associated with healing. Remodelling of the airways can be demonstrated by the activation of airways macrophages, the release of growth factors and fíbrogenic cytokines, the activation of fibroblasts and myofibroblast, elastolysis and elastosynthesis, collagen deposition, increased synthesis and release of extracellular matrix components, and an increased mass of smooth muscle and mucous glands. However, the control of remodelling is still poorly understood.