High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
2008; American Association for the Advancement of Science; Volume: 320; Issue: 5881 Linguagem: Inglês
10.1126/science.1158136
ISSN1095-9203
AutoresDavid Belin, Adam C. Mar, Jeffrey W. Dalley, Trevor W. Robbins, Barry J. Everitt,
Tópico(s)Stress Responses and Cortisol
ResumoBoth impulsivity and novelty-seeking have been suggested to be behavioral markers of the propensity to take addictive drugs. However, their relevance for the vulnerability to compulsively seek and take drugs, which is a hallmark feature of addiction, is unknown. We report here that, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration, high impulsivity predicts the development of addiction-like behavior in rats, including persistent or compulsive drug-taking in the face of aversive outcomes. This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction.
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