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Efficacy of 12 Months' Misoprostol as Prophylaxis against IMSAID-induced Gastric Ulcers: A placebo-controlled trial

1994; Taylor & Francis; Volume: 23; Issue: 4 Linguagem: Inglês

10.3109/03009749409103056

1502-7732

S. L. Elliott, Neville D. Yeomans, Russell Buchanan, R. A. Smallwood,

Nosocomial Infections in ICU

AbstractWe performed a 12-month, double-blind, randomised, placebo-controlled study to determine the long term effect of misoprostol (600–800 μg/d) in the prevention of gastric ulcers and gastroduodenal erosions in 83 arthritis patients on chronic NSAID therapy. Patients underwent endoscopy at 0, 3, 6 and 12 months. At the initial endoscopy, 12 patients had an ulcer (11 gastric), which was healed prior to randomization. Seventy eligible patients reached the 3 month endoscopy. Four (12.5%) of the 32 patients given misoprostol developed a gastric ulcer compared with 11 (28.9%) of the 38 on placebo (p<0.05, life-table analysis). Six of the 11 patients with an initial gastric ulcer developed a further gastric ulcer, compared to 9 of 58 patients without an initial ulcer (p<0.05). We conclude that misoprostol decreases the cumulative development of NSAID-induced gastric ulcers. Patients with a previous NSAID-ulcer have a higher risk of further ulceration.Key Words: prostaglandin analoguenon-steroidal anti-inflammatory agentsNSAID-induced gastropathyarthritis