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Subcutaneoous phaeohyphomycosis by Exophiala jeanselmei in a cardiac transplant recipient

2005; UNIVERSIDADE DE SÃO PAULO; Volume: 47; Issue: 1 Linguagem: Inglês

10.1590/s0036-46652005000100009

1678-9946

Maria do Rosário R. Silva, Orionalda de F.L. Fernandes, Carolina R. Costa, Aiçar Chaul, Luciano Ferreira Morgado, Luis Fernando Fleury-Júnior, Maurício Barcelos Costa,

Antifungal resistance and susceptibility

We report a case of phaeohyphomycosis caused by Exophiala jeanselmei in a cardiac transplant recipient maintained on immunosuppressive therapy with mycophenolate mofetil tacrolimus and prednisone. The lesion began after trauma on the right leg that evolved to multiple lesions with nodules and ulcers. Diagnosis was performed by histological examination and culture of pus from skin lesions. Treatment consisted of itraconazole (200 mg/day) for three months with no improvement and subsequently with amphotericin B (0.5 mg/Kg per day to a total of 3.8 g intravenously). After four months of treatment, the lesions showed marked improvement with reduction in the swelling and healing of sinuses and residual scaring.