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Dietary-induced myocardial infarction in rats: The possible role of essential fatty acid deficiency

1962; Elsevier BV; Volume: 1; Issue: 1 Linguagem: Inglês

10.1016/0014-4800(62)90003-5

1096-0945

R.F. Scott, H. Imai, F. Goodale, Kyu Taik Lee, E.S. Morrison,

Cardiovascular Disease and Adiposity

A 40% butter infarct-producing diet and a 40% butter diet supplemented with 10% purified linoleic acid were fed to two groups of rats. Both diets resulted in an equal number of infarcts and similar serum lipid values over a 5-month period. Vapor phase chromatographic analyses of the fatty acids of adipose tissue in the two groups suggested that neither suffered from EFA deficiency and that in rats receiving these two diets the differing levels of adipose tissue linoleic acid did not reflect the animals' susceptibility to infarction. In a group of animals receiving a diet in which the 40% butter was replaced by 40% corn oil, no infarcts, relatively low serum lipids, and very high adipose tissue linoleic acid levels were found. In a group of animals receiving the same diet but with sucrose substituted for the corn oil, as many infarcts were present as in the butter or butter-linoleic group, and the serum lipids were greatly elevated. Comparison of the number of infarcts and serum lipids in the corn oil diet and the diet in which sucrose replaced corn oil suggests that corn oil at the 40% level actively lowers serum lipids and modifies the incidence of infarcts in rats receiving infarct-producing diets.