Cyclophosphamide derivatives for in vitro cleansing of leukemic bone marrow
1985; Elsevier BV; Volume: 28; Issue: 5 Linguagem: Inglês
10.1016/s0338-4535(85)80017-9
ISSN1878-2183
Autores Tópico(s)Hematopoietic Stem Cell Transplantation
ResumoI N VITRO c h e m o t h e r a p y in view of e l iminat ing residual leukemic cells f r o m h u m a n autologous graf ts has been invest igated since initial r epo r t of SHARKIS et al. [1] on cyc lophosphamide derivat ives effect on ra t l eukemic cells. Such in v i t ro c h e m o t h e r a p y should be as selective as possible. Unfor tunate ly , due to its cytotoxic mecanism, it is no t so. Therefore , precl inical s tudies had to invest igate the effect of such drugs on l eukemic cells in compar i son to n o r m a l s tem cells in view of es tabl ishing highly efficient t u m o r cell killing while spar ing enough no rm a l s t e m cells to ensure engraftment . Studies rely on two CY derivat ives, 4 Hydroperoxycyclophosphamide and Asta Z 7557, which are; up to now, the only chemother apeu t i c agents used for clinical trials.
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