Proazulenes from Achillea asplenifolia
1992; Elsevier BV; Volume: 31; Issue: 12 Linguagem: Inglês
10.1016/0031-9422(92)80478-w
ISSN1873-3700
AutoresUlrike Kastner, J. Jurenitsch, Sabine Glasl, Andreas Baumann, Wolfgang Robien, W. Kubelka,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoFrom flower heads of Achillea asplenifolia Vent. the eight major proazulenes were isolated by repeated column chromatography and HPLC. By 1H NMR and mass spectral studies, especially by measurements of NOE effects, four compounds were shown to be the first 7,8-guaianolide derivatives found in the Achillea millefolium group. They were identified as 4α-hydroxy-6α-angeloxy-9α-acetoxy-5αH,7αH,8βH,11αH-guai-1(10),2-dien-7,8-olide and the respective 6α-tigloxy, 6α-acetoxy and 4-epi derivatives. One of the proazulenes was identified as 8-deacetyl-4-epi-matricin. The other three proazulenes represent the same 10-epi-artabsin derivatives as recently found in A. roseo-alba and A. collina, namely 8α-acetoxy-10-epi-artabsin (achillicin), 8α-angeloxy-10-epi-artabsin and 8α-tigloxy-10-epi-artabsin.
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