Inhibition by Ketotifen of Idiosyncratic Reactions to Aspirin
1980; Wiley; Volume: 35; Issue: 5 Linguagem: Inglês
10.1111/j.1398-9995.1980.tb01788.x
ISSN1398-9995
AutoresA Szczeklik, G Czerniawska-Mysik, M. Serwoǹgska, P. Kuklińgska,
Tópico(s)Asthma and respiratory diseases
ResumoKetotifen administered prior to aspirin offered protection against bronchoconstriction in 13 of 14 patients with aspirin‐sensitive asthma. In four other subjects, suffering from urticaria/angioedema following ingestion of aspirin‐like drugs, pretreatment with ketotifen resulted in total prevention of the adverse reactions. These results support the suggestion of a common pathogenetic mechanism operating in two distinct clinical patterns of idiosyncrasy to aspirin and other cyclo‐oxygenase inhibitors. They also indicate that ketotifen might find application in treatment of adverse reactions to aspirin.
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