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More on Chenodiol: Continued Treatment and Prevention of Recurrences

1984; American College of Physicians; Volume: 100; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-100-3-450

1539-3704

Robert H. Palmer,

Esophageal and GI Pathology

Editorials1 March 1984More on Chenodiol: Continued Treatment and Prevention of RecurrencesROBERT H. PALMER, M.D.ROBERT H. PALMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-3-450 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe results of the National Cooperative Gallstone Study reported in 1981 (1) were disappointing. After patients received chenodiol, 750 or 375 mg/d, or placebo for 2 years, complete dissolution of gallstones occurred in 13.5%, 5.2%, and 0.8%, respectively; partial dissolution (> 50%) occurred in 27.3%, 18.4%, and 10.2%. Two reasons for the poor response have been proposed (2): First, because the dose was suboptimal (as we now know) and for other reasons, bile may have been inadequately desaturated. Second, characteristics of the stones themselves may have prevented dissolution. If desaturation was inadequate, a longer period of treatment (or other measures)...References1. SCHOENFIELDLACHIN LJ. Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the National Cooperative Gallstone Study: a controlled trial of efficacy and safety. Ann Intern Med. 1981;95:257-82. LinkGoogle Scholar2. PALMERCAREY RM. An optimistic view of the National Cooperative Gallstone Study. N Engl J Med. 1982;306:1171-4. CrossrefMedlineGoogle Scholar3. MARKSBAUMHANSON JRR. Additional chenodiol therapy after partial dissolution of gallstones with two years of treatment. Ann Intern Med. 1983;100:382-4. LinkGoogle Scholar4. FREILICHMALETSCHWARTZSOLOWAY HPJR. Pigmented periphery of cholesterol gallstones retards dissolution with chenodiol in the National Cooperative Gallstone Study (NCGS) [Abstract]. Gastroenterology. 1983;84:1159. Google Scholar5. MARKSLAN JS. Low-dose chenodiol to prevent gallstone recurrence after dissolution therapy. Ann Intern Med. 1983;100:376-81. LinkGoogle Scholar6. THISTLE J. Medical treatment of gallstones. Pract Gastroenterol. 1981;5:31-8. Google Scholar7. RUPPINDOWLING DR. Is recurrence inevitable after gallstone dissolution by bile-acid treatment? Lancet. 1982;1:181-5. CrossrefMedlineGoogle Scholar8. LANZINIKUPFERJOSEPHNORTHFIELD ARAT. Has the risk of gallstone recurrence following medical dissolution been overestimated [Abstract]! Gastroenterology. 1983;84:1224. Google Scholar9. TOULETROUSSELETVITEAU JJJ. Récidives et prévention des récidives apres dissolution de la lithiase vésiculaire par l'acide chénodésoxycholique chez 22 patients. Gastroenterol Clin Biol. 1983;7:605-9. MedlineGoogle Scholar10. SHAPEROLEEWILSONROSENFISHER TVRIM. A problem in the evaluation of gallstone dissolution [Abstract]. Gastroenterology. 1981;80:1348. Google Scholar11. SOMERVILLEROSEBELLELLISKNAPP KDGWD. Gallstone dissolution and recurrence: are we being misled? Br Med J [Clin Res]. 1982;284:1295-7. CrossrefMedlineGoogle Scholar12. LEFKOFFRENKIELLEE IPD. Assessment of diets and ultrasonography versus cholecystography in ursodeoxycholic acid-induced gallstone dissolution [Abstract]. Gastroenterology. 1983;84:1227. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT H. PALMER, M.D.Affiliations: Columbia University College of Physicians and Surgeons New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA history of the dissolution of retained choledocholithiasisAgents for gallstone dissolutionSouthwestern Internal Medicine Conference: Cholesterol Gallstone Disease: The Current Status of Nonsurgical TherapyGALLSTONES—SURGERY SOLVENTS OR SHOCKWAVESCholelithiasisAgents for gallstone dissolutionMedical Management of Cholesterol GallstonesDissolution of Gallstones by Methyl Tert-Butyl Ether 1 March 1984Volume 100, Issue 3Page: 450-451KeywordsBile ePublished: 1 December 2008 Issue Published: 1 March 1984 PDF downloadLoading ...