Portal de Periódicos da CAPES

In vivo model for frontal sinus and calvarial bone defect obliteration with bioactive glass S53P4 and hydroxyapatite

2001; Wiley; Volume: 58; Issue: 3 Linguagem: Inglês

10.1002/1097-4636(2001)58

1097-4636

Matti Peltola, Kalle Aitasalo, Jouko T. K. Suonp��, Antti Yli‐Urpo, Pékka Laippala,

Facial Trauma and Fracture Management

Journal of Biomedical Materials ResearchVolume 58, Issue 3 p. 261-269 Research Report In vivo model for frontal sinus and calvarial bone defect obliteration with bioactive glass S53P4 and hydroxyapatite Matti J. Peltola, Corresponding Author Matti J. Peltola Department of Otorhinolaryngology — Head and Neck Surgery, Turku University Central Hospital, FinlandDepartment of Otorhinolaryngology — Head and Neck Surgery, Turku University Central Hospital, FIN-20521 Turku, FinlandSearch for more papers by this authorKalle M. J. Aitasalo, Kalle M. J. Aitasalo Department of Otorhinolaryngology — Head and Neck Surgery, Turku University Central Hospital, FinlandSearch for more papers by this authorJouko T. K. Suonpää, Jouko T. K. Suonpää Department of Otorhinolaryngology — Head and Neck Surgery, Turku University Central Hospital, FinlandSearch for more papers by this authorAntti Yli–Urpo, Antti Yli–Urpo Institute of Dentistry, University of Turku, FinlandSearch for more papers by this authorPekka J. Laippala, Pekka J. Laippala Tampere School of Public Health, University of Tampere and Tampere University Hospital, FinlandSearch for more papers by this author Matti J. Peltola, Corresponding Author Matti J. Peltola Department of Otorhinolaryngology — Head and Neck Surgery, Turku University Central Hospital, FinlandDepartment of Otorhinolaryngology — Head and Neck Surgery, Turku University Central Hospital, FIN-20521 Turku, FinlandSearch for more papers by this authorKalle M. J. Aitasalo, Kalle M. J. Aitasalo Department of Otorhinolaryngology — Head and Neck Surgery, Turku University Central Hospital, FinlandSearch for more papers by this authorJouko T. K. Suonpää, Jouko T. K. Suonpää Department of Otorhinolaryngology — Head and Neck Surgery, Turku University Central Hospital, FinlandSearch for more papers by this authorAntti Yli–Urpo, Antti Yli–Urpo Institute of Dentistry, University of Turku, FinlandSearch for more papers by this authorPekka J. Laippala, Pekka J. Laippala Tampere School of Public Health, University of Tampere and Tampere University Hospital, FinlandSearch for more papers by this author First published: 31 July 2002 https://doi.org/10.1002/1097-4636(2001)58:3 3.0.CO;2-7Citations: 21Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract An in vivo model was developed to investigate the usability of a frontal sinus and a calvarial bone defect obliteration with bioactive glass S53P4 (BG) and hydroxyapatite (HA) granules. Roofs of 21 Elco rabbit frontal sinuses were drilled open from 4 separate holes using a standard method, and the sinuses, located in pairs, in frontal bone were filled with BG on one side and with HA on the other side. Two parallel posterior defects were covered with a pedicled periosteum flap, and 2 anterior defects with a free flap. The stability of materials, new bone, and connective tissue formation were observed with histomorphometry, scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDXA), and X-ray pictures at 1, 3, 6, and 12 months postoperatively. The results showed more rapid resorption of filling material (p = 0.019) and new bone formation (p = 0.0001) in the defects filled with BG than in the corresponding HA-filled defects studied by histomorphometry throughout the study. New bone formation and resorption of materials were faster in defects covered by a pedicled flap than by a free periosteum flap. The results were supported by SEM histomorphometric and radiologic analysis. Both bioactive materials studied were well tolerated in frontal sinuses and in calvarial bone defects. The experimental model showed the influence of early periosteum vascularization on accurate frontal sinus filling and the healing process in rabbit frontal sinuses. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res (Appl Biomater) 58: 261–269, 2001 REFERENCES 1 Weber R, Draf W, Kahle G, Kind M. Obliteration of the frontal sinus-state of the art and reflections on new materials. Rhinology 1999; 37: 1– 15. 2 Heikkilä JT, Aho AJ, Yli–Urpo A, Andersson ÖH, Aho HJ, Happonen RP. Bioactive glass versus hydroxyapatite in reconstruction of osteochondral defects in the rabbit. Acta Orthop Scand 1993; 64: 678– 682. 3 Schephers EJ, Duchuyene P. Bioactive glass particles of narrow size range for the treatment of oral bone defects: a 1–24 month experiment with several materials and particle sizes and size ranges. J Oral Rehab 1997; 24: 171– 181. 4 Zamet JS, Darbar UR, Griffiths GS, Bulman JS, Bragger U, Burgin W, Newman HN. Particulate bioglass as a grafting material in the treatment of periodontal intrabony defects. J Clin Periodontology 1997; 24: 410– 418. 5 Reck R, Storkel S, Meyer A. Bioactive glass-ceramics in middle ear surgery. An 8-year review. Ann NY Acad Sci 1988; 523: 100– 106. 6 Nagasae M, Abe Y, Chikira M, Udagawa E. Toxicity of silica containing calcium phosphate glasses demonstrated in mice. Biomater 1992; 13: 172– 175. 7 Wilson J, Pigott GH, Schoen FJ, Hench LL. Toxicology and biocompactibility of bioglasses. J Biomed Mater Res 1981; 15: 805– 817. 8 Peltola MJ, Suonpää JTK, Andersson ÖH, Määttänen HS, Aitasalo KMJ, Yli–Urpo A, Laippala PJ. In vitro model for frontal sinus obliteration with bioactive glass S53P4. J Biomed Mater Res (Appl Biomater) 2000; 53: 161– 166. 9 Peltola M, Suonpää J, Aitasalo K, Yli–Urpo A, Andersson Ö, Laippala P. Experimental in vitro study of the dissolution of bioactive glass (S53P4) in amounts used in the obliteration the larger bone cavities. Bioceram 1999; 12: 41– 44. 10 Peltola M, Suonpää J, Aitasalo K, Andersson Ö, Määttänen H, Yli–Urpo A. Long-term reactions in vitro with bioactive glass S53P4. Bioceram 1998; 11: 129– 132. 11 Aitasalo K, Peltola M, Suonpää J, Yli–Urpo A, Andersson Ö, Varpula M, Happonen RP. Obliteration of frontal sinuses with bioactive glass after chronic suppurative sinusitis. One year follow-up. Bioceram 1994; 7: 409– 414. 12 Aitasalo K, Suonpää J, Peltola M, Yli–Urpo A. Behaviour of bioactive glass (S53P4) in human frontal sinus obliteration. Bioceram 1997; 10: 429– 432. 13 Peltola M, Suonpää J, Aitasalo K, Varpula M, Yli–Urpo A, Happonen RP. Obliteration of frontal sinus cavity with bioactive glass. Head Neck 1998; 20: 315– 319. 14 Virolainen P, Heikkilä J, Yli–Urpo A, Vuorio E, Aro HT. Histomorphometric and molecular biologic comparison of bioactive glass granules and autogenous bone grafts in augmentation of bone defect healing. J Biomed Mater Res 1997; 35: 9– 17. 15 Fujita H, Nakamura T, Tamura J, Kobayashi M, Katsura Y, Kokubo T, Kikutani T. Bioactive bone cement: effect of the amount of glass-ceramic powder on bone-bonding strength. J Biomed Mater Res 1998; 40: 145– 152. 16 Hall EE, Meffert RM, Herman JS, Mellonig JT, Cochran DL. Comparison of bioactive glass to demineralized freeze-dried bone allograft in the treatment of intrabony defects around implants in the canine mandible. J Periodontol 1999; 70: 526– 535. 17 Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop 1981; 157: 259– 278. 18 Cook SD, Thomas KA, Kay JF, Jarcho M. Hydroxyapatite coated porous titanium for use as an orthopedic biologic attachment system. Clin Orthop 1988; 230: 303– 312. 19 Evans GH, Mendez AJ, Caudill RF. Loaded and nonloaded titanium versus hydroxyapatite coated threaded implants in the canine mandible. Int J Oral Maxillofacial Impl 1996; 11: 360– 371. 20 Constantino PD, Friedman CD, Jones K, Chow LC, Pelzer HJ, Sisson GA. 1991. Hydroxyapatite cement II. Obliteration and reconstruction of the cat frontal sinus. Arch Otolaryngol Head Neck Surg 1991; 117: 385– 389. 21 Rosen G, Nachtigal D. The use of hydroxyapatite for obliteration of the human frontal sinus. Laryngoscope 1995; 105: 553– 555. 22 Turunen T, Peltola J, Helenius H, Yli–Urpo A, Happonen RP. Bioactive glass and calcium carbonate granules as filler material around titanium and bioactive glass implants in the medullar space of the rabbit tibia. Clin Oral Impl Res 1997; 8: 96– 102. 23 Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. J Oral Pathol 1982; 11: 318. 24 Heikkilä JT, Beliaev N, Yli–Urpo A, Aho AJ. Staining characteristics of bone and bioactive glass for manual and computerized histomorphometry. Bioceram 1995; 8: 505– 508. 25 Damien CJ, Parsons JR. Bone graft and bone graft substitutes: A review of current technology and applications. J Appl Biomater 1991; 2: 187– 208. 26 Uddströmer L, Ritsilä V. Osteogenic capacity of periosteal grafts. A qualitative and quantitative study of membranous and tubular bone periosteum in young rabbits. Scand J Plastic Reconstruct Surg 1978; 12: 207– 214. 27 LeGeros RZ, Parsons JR, Daculsi G, Lee D, Liu ST, Peterson M, Walker M. Significance of the porosity and physical chemistry of calcium phosphate ceramics. Biodegradation-bioresorption. Ann NY Acad Sci 1988; 523: 268– 271. 28 Gomi K, Lowenberg B, Shapiro G, Davies JE. Resorption of sintered synthetic hydroxyapatite by osteoclasts in vitro. Biomater 1993; 14: 91– 96. 29 Cancian DC, Hochuli–Vieira E, Marcantonio RA, Marcantonio E Jr. Use of BioGran and Calcitite in bone defects: histologic studies in monkeys (Cebus apella). Int J Oral Maxillofac Impl 1999; 14: 859– 864. 30 Suominen EA, Kinnunen J. Bioactive glass granules and plates in the reconstruction of defects of the facial bones. Scand J Plast Reconstr Surg Hand Surg 1996; 30: 281– 289. Citing Literature Volume58, Issue32001Pages 261-269 ReferencesRelatedInformation