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The Pharmacology of Monoclonal Antibodiesa

1987; Wiley; Volume: 507; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1987.tb45802.x

1749-6632

John N. Weinstein, Renee R. Eger, David G. Covell, C D Black, James L. Mulshine, Jorge A. Carrasquillo, Steven M. Larson, Andrew M. Keenan,

Toxin Mechanisms and Immunotoxins

Annals of the New York Academy of SciencesVolume 507, Issue 1 p. 199-210 The Pharmacology of Monoclonal Antibodiesa J. N. WEINSTEIN, J. N. WEINSTEIN National Cancer Institute National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorR. R. EGER, R. R. EGER National Cancer Institute National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorD. G. COVELL, D. G. COVELL National Cancer Institute National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorC. D. V. BLACK, C. D. V. BLACK National Cancer Institute National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorJ. MULSHINE, J. MULSHINE NCI-Navy Medical Oncology Branch Naval Hospital National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorJ. A. CARRASQUILLO, J. A. CARRASQUILLO Clinical Center National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorS. M. LARSON, S. M. LARSON Clinical Center National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorA. M. KEENAN, A. M. KEENAN Clinical Center National Institutes of Health Bethesda, Maryland 20892Search for more papers by this author J. N. WEINSTEIN, J. N. WEINSTEIN National Cancer Institute National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorR. R. EGER, R. R. EGER National Cancer Institute National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorD. G. COVELL, D. G. COVELL National Cancer Institute National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorC. D. V. BLACK, C. D. V. BLACK National Cancer Institute National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorJ. MULSHINE, J. MULSHINE NCI-Navy Medical Oncology Branch Naval Hospital National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorJ. A. CARRASQUILLO, J. A. CARRASQUILLO Clinical Center National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorS. M. LARSON, S. M. LARSON Clinical Center National Institutes of Health Bethesda, Maryland 20892Search for more papers by this authorA. M. KEENAN, A. M. KEENAN Clinical Center National Institutes of Health Bethesda, Maryland 20892Search for more papers by this author First published: December 1987 https://doi.org/10.1111/j.1749-6632.1987.tb45802.xCitations: 84 a The work of R.R.E. was supported by a gift from Hybritech, Inc. to the Cancer Immunotherapy Fund. The opinions and assertions contained herein are the private views of the authors and are not to be construed as being official or reflecting the views of the Department of the Navy, Department of Defense, or Department of Health and Human Services. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Weinstein, J. N., D. G. Covell, J. Barbet, R. R. Eger, O. D. Holton III, M. J. Talley, R. J. Parker & C. D. V. Black. 1987. Local and cellular factors in the pharmacology of monoclonal antibodies. In Membrane Mediated Cytotoxicity. B. Bonavida & R. J. Collier, Eds.: 279–289. Alan R. Liss, New York . 2 Covell, D. G., J. Barbet, O. D. Holton III, C. D. V. Black & J. N. Weinstein. 1986. The pharmacokinetics of monoclonal IgGl, F(ab')2 and Fab' in mice. Cancer Res. 46: 3969–3978. 3 Covell, D. G., M. A. Steller, R. J. Parker & J. N. Weinstein. 1985. Delivery of monoclonal antibodies through the lymphatics: Characterization by compartmental modeling. Computer Appl. Med. Care 10: 884–888. 4 Holton, O. D. III, C. D. V. Black, R. J. Parker, D. G. Covell, J. Barbet, S. M. Sieber, M. J. Talley & J. N. Weinstein. 1987. Biodistribution of monoclonal IgG1, F(ab')2, and Fab' in mice after intravenous injection: A comparison between anti-B cell (anti-LyB8.2) and irelevant (MOPC-21) antibodies. J. Immunol. 5 Eger, R. R., D. G. Covell, J. A. Carrasquillo, P. G. Abrams, K. A. Foon, J. C. Reynolds, R. W. Schroff, A. C. Morgan, S. M. Larson & J. N. Weinstein. 1987. Kinetic model for the biodistribution of an 111In-labeled monoclonal antibody in humans. Cancer Res. 47: 3328–3336. 6 Carrasquillo, J. A., P. G. Abrams, R. W. Schroff, J. C. Reynolds, C. S. Woodhouse, A. C. Morgan, A. M. Keenan, K. A. Foon, P. Perentesis, S. Marshall, M. Horowitz, J. Szymendera, R. K. Oldham & S. M. Larson. 1988. Effect of 111In 9.2.27 monoclonal antibody dose on the imaging of metastatic melanoma. J. Nucl. Med. (In press.). 7 Morgan, A. C., C. S. Woodhouse, R. M. Bartholomew & R. W. Schroff. 1986. Human melanoma-associated antigens: analysis of antigenic heterogeneity by molecular, serologic, and flow cytometric approaches. Mol. Immunol. 23: 193–200. 8 Stuhlmiller, G. M., M. J. Borowitz, B. P. Croker & H. F. Seigler. 1982. Multiple assay characterization of murine monoclonal anti-melanoma antibodies. Hybridoma 1: 447–460. 9 Koizumi, K., G. L. DeNardo, S. J. DeNardo, M. T. Hays, H. H. Hines, P. O. Scheibe, J. Peng, D. J. Macey, N. Tonami & K. Hisada. 1986. Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibodies in patients with cancer. J. Nucl. Med. 27: 1243–1254. 10 Weinstein, J. N., O. D. Holton III, C. D. V. Black, A. M. Keenan, D. G. Covell, G. F. Spaulding, J. Barbet, M. S. Steller, S. M. Sieber, M. J. Talley & R. J. Parker. 1986. Regional delivery of monoclonal antitumor antibodies: Detection and possible treatment of lymph node metastases. In Cancer Metastasis: Experimental and Clinical Strategies. D. R. Welch, B. K. Bhuyan & L. A. Liotta, Eds.: 169–180. Alan R. Liss. New York . 11 Weinstein, J. N., R. J. Parker, A. M. Keenan, S. K. Dower, H. C. Morse III & S. M. Sieber. 1982. Monoclonal antibodies in the lymphatics: Toward the diagnosis and therapy of tumor metastases. Science 218: 1334–1337. 12 Weinstein, J. N., M. A. Steller, D. G. Covell, O. D. Holton III, A. M. Keenan, S. M. Sieber & R. J. Parker. 1984. Monoclonal anti-tumor antibodies in the lymphatics. Cancer Treat. Rep. 68: 257–264. 13 Weinstein, J. N., R. J. Parker, O. D. Holton III, A. M. Keenan, D. G. Covell, C. D. V. Black & S. M. Sieber. 1985. Lymphatic delivery of monoclonal antibodies: Potential for detection and treatment of lymph node metastases. Cancer Invest. 3: 85–95. 14 Steller, M. A., R. J. Parker, D. G. Covell, O. D. Holton III, A. M. Keenan, S. M. Sieber & J. N. Weinstein. 1986. Optimization of monoclonal antibody delivery via the lymphatics: The dose-dependence. Cancer Res. 46: 1830–1834. 15 Weinstein, J. N., M. A. Steller, A. M. Keenan, D. G. Covell, M. E. Key, S. M. Sieber, R. K. Oldman, K. M. Hwang & R. J. Parker. 1983. Monoclonal antibodies in the lymphatics: Selective delivery to lymph node metastases of a solid tumor. Science 222: 423–426. 16 Mulshine, J. L., A. M. Keenan, J. A. Carrasquillo, T. Walsh, R. I. Linnoila, O. D. Holton III, J. Harwell, S. M. Larson, P. A. Bunn & J. N. Weinstein. 1987. Immunolymphoscintigraphy of pulmonary and mediastinal lymph nodes in dogs: A new approach to lung cancer imaging. Cancer Res. 47: 3572–3576. 17 Watanabe, M., T. Suzuki, M. Taniguchi & N. Shinohara. 1983. Monoclonal anti-la murine allo antibodies cross reactive with the Ia-homologies of other mammalian species including humans. Transplantation 36: 712–718. 18 Order, S. E., W. D. Bloomer, A. G. Jones, W. D. Kaplan, M. A. Davis, S. J. Adelstein & S. Hellman. 1975. Radionuclide immunoglobulin lymphangiography: A case report. Cancer 35: 1487–1492. 19 Order, S. E. 1977. Immunospecific radionuclide immunoglobulin lymphography. In Clinical Lymphography. M. E. Clouse, Ed. 7: 316–322. Williams and Wilkins. Baltimore . 20 DeLand, F. H., E. E. Kim, R. L. Corgan, S. Casper, F. J. Primus, E. Spremulli, N. Estes & D. M. Goldenberg. 1979. Axillary lymphoscintigraphy by radioimmunodetection of carcinoembryonic antigen in breast cancer. J. Nucl. Med. 20: 1243–1250. 21 DeLand, F. H., E. E. Kim & D. M. Goldenberg. 1980. Lymphoscintigraphy with radionuclide-labeled antibodies to carcinoembryonic antigen. Cancer Res. 40: 2997–3000. 22 Thompson, C. H., S. A. Stacker, N. Salehi, M. Lichtenstein, M. J. Leyden, J. T. Andrews & I. F. C. McKenzie. 1984. Immunoscintigraphy for detection of lymph node metastases from breast cancer. Lancet (Dec. 1): 1245–1247. 23 Lotze, M. T., J. A. Carrasquillo, J. N. Weinstein, G. J. Bryant, P. Perentesis, J. C. Reynolds, L. A. Matis, R. R. Eger, A. M. Keenan, I. Hellstrom, K-E. Hellstrom & S. M. Larson. 1986. Ann. Surgery 204: 223–235. 24 Nelp, W. B., J. F. Eary, R. F. Jones, R. Kishore, K. A. Krohn, P. L. Beaumier, K-E. Hellstrom & I. Hellstrom. 1986. Preliminary studies of radiolabeled monoclonal antibody lymphoscintigraphy in malignant melanoma. J. Nucl. Med. 26: 66. 25 Keenan, A. M., J. N. Weinstein, J. L. Mulshine, J. A. Carrasquillo, P. A. Bunn Jr., J. C. Reynolds, K. A. Foon, P. Perentesis, B. Ghosh & S. M. Larson. 1987. Evaluation of lymphoma by immunolymphoscintigraphy: Subcutaneous injection of indium-111-labeled T101 monoclonal antibody. J. Nucl. Med. 28: 42–46. 26 Poznansky, M. J. & R. L. Juliano. 1984. Pharmac. Rev. 36: 277–334. 27 Weinstein, J. N., C. D. V. Black, R. Parker, R. R. Eger, S. M. Sieber, B. Mozayeni & D. G. Covell. 1986. Selected issues in the pharmacology of monoclonal antibodies. In Site-specific Drug Delivery. E. Tomlinson & S. S. Davis, Eds.: 81–92. John Wiley. New York . 28 Meeker, T. C., J. Lowder, D. G. Maloney, R. A. Miller, K. Thielemans, R. Warnke & R. Levy. 1985. A clinical trial of anti-idiotype therapy for B cell malignancies. Blood 65: 1349–1363. 29 Abrams, P. G. & R. K. Oldham. 1985. Monoclonal antibody therapy of solid tumors. In Monoclonal Antibody Therapy of Human Cancer. K. A. Foon & A. C. Morgan, Eds.: 103. Martinus Nijhof. Boston . 30 Jones, P. L., B. M. Gallagher & H. Sands. 1986. Autoradiographic analysis of monoclonal antibody distribution in human colon and breast tumor xenografts. Cancer Immunol. Immunotherapy. 22: 139–143. 31 Swabb, E. A., J. Wei & M. Gullino. 1974. Diffusion and convection in normal and neoplastic tissues. Cancer Res. 34: 2814. 32 Houston, S. A., W. F. D. Sampson & M. A. A. MacLeod. 1979. A compartmental model for the distribution of In-113m-DTPA and Tc-99m(Sn)DTPA in man following intravenous injection. Int. J. Nucl. Med. Biol. 6: 85–95. Citing Literature Volume507, Issue1Biological Approaches to the Controlled Delivery of DrugsDecember 1987Pages 199-210 ReferencesRelatedInformation