Chemoprevention of carcinogen-DNA binding: the relative role of different oxygenated substituents on 4-methylcoumarins in the inhibition of aflatoxin B1-DNA binding in vitro
1996; Elsevier BV; Volume: 4; Issue: 12 Linguagem: Inglês
10.1016/s0968-0896(96)00227-1
ISSN1464-3391
AutoresHanumantharao G. Raj, Sangita Gupta, Gopa Biswas, Suddham Singh, A. SINGH, Amitabh Jha, Kirpal S. Bisht, Sanjeev Sharma, Subhash C. Jain, Virinder S. Parmar,
Tópico(s)Genomics, phytochemicals, and oxidative stress
ResumoEighteen 4-methylcoumarins bearing methoxy/hydroxy/acetoxy functionalities have been reported to effectively inhibit the rat liver microsome-mediated aflatoxin B1-DNA binding in vitro. The contribution of functionality on coumarin nucleus towards the inhibition of AFB1-DNA binding is in the order acetoxy > hydroxy > methoxy. The results illustrate the structure-activity relationship.
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