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Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents

2010; Elsevier BV; Volume: 45; Issue: 4 Linguagem: Inglês

10.1016/j.ejmech.2009.12.039

1768-3254

Li‐Chen Chou, Li‐Jiau Huang, Mei‐Hua Hsu, Mei‐Chi Fang, Jai‐Sing Yang, Shi‐Hong Zhuang, Hui‐Yi Lin, Fang‐Yu Lee, Che‐Ming Teng, Sheng‐Chu Kuo,

Free Radicals and Antioxidants

As part of our continuing search for potential anticancer drug candidates among YC-1 analogs, 1, 3-disubstituted selenolo[3,2-c]pyrazole derivatives were synthesized and evaluated for their cytotoxicity against NCI-H226 non-small cell lung cancer and A-498 renal cancer cell lines. Significant cytotoxicity was observed in 3-(5-hydroxymethyl-2-furyl) derivatives (2, 33, 36 and 37). Among them, compound 2 was found to have the most potent activity. The mode of action of compound 2 seems to differ from those of the 175 anticancer agents listed in NCI's standard database and resembles that of YC-1. Thus, we recommend that compound 2 should be developed further as new drug candidate for treatment of non-small cell lung cancer and renal cancer.