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c-rel activates but v-rel suppresses transcription from kappa B sites.

1991; National Academy of Sciences; Volume: 88; Issue: 9 Linguagem: Inglês

10.1073/pnas.88.9.3715

1091-6490

Jun‐ichiro Inoue, Lawrence D. Kerr, Lynn J. Ransone, Eyal Bengal, Tony Hunter, Inder M. Verma,

Immune Response and Inflammation

We show that the product of the protooncogene c-rel is a constituent of an NF-kappa B-like complex that binds to the kappa B site originally identified in the enhancer of immunoglobulin kappa light chain gene. c-rel protein synthesized in bacteria binds to the kappa B site in a sequence-specific manner. The rel-kappa B complex can be disrupted by incubation with anti-rel antibodies. The rel protein can form oligomers. The c-rel protein can activate transcription from promoters containing kappa B sites; v-rel, on the other hand, suppresses the transcription of genes linked to kappa B sites. Thus, v-rel may interfere with the normal transcriptional machinery of the cell by acting as a dominant negative mutant.