Oxidative N -Dealkylation: A Mannich Intermediate in the Formation of a New Metabolite of Lidocaine in Man
1971; American Association for the Advancement of Science; Volume: 173; Issue: 3996 Linguagem: Inglês
10.1126/science.173.3996.544
ISSN1095-9203
AutoresGeorge D. Breck, William Trager,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoEvidence is presented for a new metabolite of lidocaine. Its structure, N(1)-ethyl-2-methyl-N(3)-(2,6-dimethylphenyl)-4-imidazolidinone, suggests reactive electrophilic intermediates for the oxidative removal of N-alkyl groups in general.
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