Proliferative Index Determination in Prostatic Carcinoma Tissue: Is There Any Additional Prognostic Value Greater Than That of Gleason Score, Ploidy and Pathological Stage?
1997; Lippincott Williams & Wilkins; Volume: 157; Issue: 1 Linguagem: Inglês
10.1016/s0022-5347(01)65329-1
ISSN1527-3792
AutoresL. Coetzee, Lester J. Layfield, Veronika Hars, David F. Paulson,
Tópico(s)Urologic and reproductive health conditions
ResumoNo AccessJournal of UrologyClinical Urology: Original Article1 Jan 1997Proliferative Index Determination in Prostatic Carcinoma Tissue: Is There Any Additional Prognostic Value Greater Than That of Gleason Score, Ploidy and Pathological Stage? Lance J. Coetzee, Lester J. Layfield, Veronika Hars, and David F. Paulson Lance J. CoetzeeLance J. Coetzee More articles by this author , Lester J. LayfieldLester J. Layfield More articles by this author , Veronika HarsVeronika Hars More articles by this author , and David F. PaulsonDavid F. Paulson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65329-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The proliferative index was evaluated as an additional prognostic variable in 244 radical prostatectomy specimens from patients with prostate cancer. This study was done on the grounds that this variable has shown some promise as a prognostic tool in some other carcinomas, for example breast cancer. Materials and Methods: The proliferative index was evaluated in 244 patients undergoing radical prostatectomy for clinically localized disease between January 1988 and August 1994. Proliferative index was determined using the Ki-67 antibody on fresh frozen tissue and MIB-1 on paraffin embedded tissues. Patients were divided into 2 groups based on a proliferative index of less than 1 (185) or 1 or greater (59). Of the patients 49 (20%) had biochemical failure (median 23 months to progressive prostate specific antigen elevation of 0.5 ng./ml. or more). Those whose treatment failed were also divided into 2 groups according to proliferative index: 32 of 185 (18%) with an index of less than 1 and 17 of 59 (27%) with an index of 1 or more. Gleason score and deoxyribonucleic acid ploidy status were also evaluated in all patients and compared in multivariate regression analysis. Operative specimens were categorized as organ confined, specimen confined or margin positive. Results: The distribution according to margin status in the 2 groups (proliferative index less than 1 and 1 or more) was 40 versus 60% for organ confined, 67 versus 33% for specimen confined and 72 versus 28% for margin positive disease, respectively. The distribution of time to treatment failure in the 2 groups was not markedly different: 7.2 versus 9.4 months for margin positive, 10 versus 14.5 months for specimen confined and 8.5 versus 12 months for organ confined cancer, respectively. Conclusions: Multivariate analysis demonstrated that, although deoxyribonucleic acid ploidy seemed to correlate with more advanced disease, only Gleason sum and pathological T stage reached statistical significance when evaluated against time to treatment failure. 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Abstract, Google Scholar Division of Urology, Departments of Surgery, Radiation Oncology and Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byISELIN C, ROBERTSON J and PAULSON D (2018) RADICAL PERINEAL PROSTATECTOMY: ONCOLOGICAL OUTCOME DURING A 20-YEAR PERIODJournal of Urology, VOL. 161, NO. 1, (163-168), Online publication date: 1-Jan-1999.BORRE M, BENTZEN S, NERSTROM B and OVERGAARD J (2018) TUMOR CELL PROLIFERATION AND SURVIVAL IN PATIENTS WITH PROSTATE CANCER FOLLOWED EXPECTANTLYJournal of Urology, VOL. 159, NO. 5, (1609-1614), Online publication date: 1-May-1998. Volume 157Issue 1January 1997Page: 214-218 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Lance J. Coetzee More articles by this author Lester J. Layfield More articles by this author Veronika Hars More articles by this author David F. 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