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RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila

2006; American Association for the Advancement of Science; Volume: 312; Issue: 5772 Linguagem: Inglês

10.1126/science.1125694

1095-9203

Xiaohong Wang, Roghiyh Aliyari, Wan-Xiang Li, Hong-Wei Li, Kevin Kim, Richard W. Carthew, Peter W. Atkinson, Shou‐Wei Ding,

Mosquito-borne diseases and control

Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila . Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.