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Insulin and estrogen regulation of lipid synthesis in adipose tissue

1966; Elsevier BV; Volume: 116; Issue: 2 Linguagem: Inglês

10.1016/0005-2760(66)90005-1

1879-145X

Kay E. Gilmour, Kenneth W. McKerns,

Fatty Acid Research and Health

1. The addition of estrone, estradiol and estriol at extremely low levels (10−9 μmoles/ml) stimulates the synthesis of tritium-labeled lipids from [1-3H]glucose by-sections of adipose tissue of the female rat in vitro. 2. There is a marked synergistic action of estradiol with insulin on the stimulation of lipid synthesis from glucose by the adipose tissue of the female rat. 3. The adipose tissue of the male rat fails to respond to estrogen in vitro but is stimulated by insulin. 4. Other steroid hormones such as cortisol, progesterone, dehydroepiandrosterone and testosterone were without significant effect on the synthesis of lipid from [1-3H]glucose in adipose tissue from the female rat. 5. A homogenate system was prepared from adipose tissue from female rats which rapidly synthesized tritium-labeled lipids from [1-3H]glucose and [1-3H]glucose 6-phosphate but preliminary experiments have not demonstrated any response to insulin or estrogen.