Portal de Periódicos da CAPES

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations

2014; Elsevier BV; Volume: 125; Issue: 1 Linguagem: Inglês

10.1182/blood-2014-07-591529

1528-0020

Vincent‐Philippe Lavallée, Patrick Gendron, Sébastien Lemieux, Giovanni D’Angelo, Josée Hébert, Guy Sauvageau,

RNA Research and Splicing

Key Points EVI1-r AMLs have recurrent mutations in RAS and other signaling genes, splicing factors, and at a lower frequency, IKZF1 and TP53. EVI1-r AMLs show a characteristic transcriptome profile marked by high expression of MECOM, PREX2, MYCT1, PAWR, and VIP.