Comparative Study of Selected Coupling Reagents in Dipeptide Synthesis
1993; Taylor & Francis; Volume: 23; Issue: 3 Linguagem: Inglês
10.1080/00397919308009787
ISSN1532-2432
AutoresJoseph Dudash, Jianjun Jiang, Scott C. Mayer, Madeleine M. Joullié,
Tópico(s)Chemical Reactions and Isotopes
ResumoAbstract A comparative study of the effectiveness of selected coupling reagents in dipeptide synthesis was conducted. Included in the study were a new coupling reagent, pentafluorophenyl diphenylphosphinate (FDPP, 1), benzotriazol-1-yl-oxytris(dimethylamino) phosphonium hexafluorophosphate (BOP, 2), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU, 3), and isobutyl chloroformate (IBCF, 4). We found that BOP (2) afforded the highest yields and lowest limits of racemization.
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