Alveolar wound healing alteration under uranyl nitrate intoxication
1985; Wiley; Volume: 14; Issue: 7 Linguagem: Inglês
10.1111/j.1600-0714.1985.tb00530.x
ISSN1600-0714
AutoresM. B. Guglelmotti, A. M. Ubios, R. L. Cabrini,
Tópico(s)Veterinary Pharmacology and Anesthesia
ResumoThe deposit of uranium compounds in calcifying zones has been demonstrated in hone. Nevertheless, no studies on the effect of uranium on osteogenesis have been performed. A histologic and histometric study of the effect of a single intraperitoneal injection of 2 mg/kg of body weight of uranyl nitrate on bone formation is presented. It was performed on rats' healing sockets. 14 days after tooth extraction. The alveolar bone volume (15 × 10 5 μm 2 vs. 34 × 10 5 μm 2 ), total bone formation areas (4.85% vs. 19.55%). and volume density of bone in the alveolar apical third (0.26 vs. 0.40) were significantly lower in intoxicated animals than in the controls. These results indicate the inhibitory effect of uranyl nitrate on bone formation.
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