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Total Synthesis of (+)-Galbulimima Alkaloid 13 and (+)-Himgaline

2007; American Chemical Society; Volume: 129; Issue: 5 Linguagem: Inglês

10.1021/ja0684996

1943-2984

David A. Evans, Drew Adams,

Alkaloids: synthesis and pharmacology

The stereoselective syntheses of (+)-himgaline (1) and (+)-GB13 (2) are described. Important diastereoselective bond constructions include an intramolecular Diels−Alder reaction, an intramolecular Michael addition, and an intramolecular enamine aldol addition.