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Adhesion Molecule Expression on B-Cells from Acute and Chronic Lymphoid Leukemias

1994; Taylor & Francis; Volume: 16; Issue: 1-2 Linguagem: Inglês

10.3109/10428199409114137

1042-8194

Giulio Rossi, Claudya Tenca, G Cerruti, A. Favre, Daniela Zarcone, Antonio Tabilio, Francesca Romana Mauro, Luciana Annino, C. E. Grossit,

Monoclonal and Polyclonal Antibodies Research

Adhesion molecule expression on acute and chronic lymphoid leukemia cells of B lineage (B-ALL and B-CLL) may subserve several functions. Adhesion of leukemic cells to endothelial cells and to extracellular matrix components is relevant to homing, trafficking and spread of the malignant cells, and thus to clinical presentation, course and disease prognosis. Adhesive interactions between malignant cells and accessory cells, particularly stromal cells in the bone marrow environment, may support growth of the malignant cells via cytokine-delivered messages. They may also deliver signals that prevent or trigger programmed cell death of tumor cells.