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Significance of Intraperitoneal Cytology in Patients Undergoing Radical Hysterectomy

1998; Elsevier BV; Volume: 68; Issue: 2 Linguagem: Inglês

10.1006/gyno.1998.4937

1095-6859

Ricardo Estape, Roberto Angioli, Felicia A. Wagman, Marilu Madrigal, Mike F. Janicek, Parvin Ganjei‐Azar, Manuel Peñalver, Hervy E. Averette,

Intraperitoneal and Appendiceal Malignancies

The incidence and prognostic significance of positive intraperitoneal cytology taken during a radical hysterectomy was reviewed. A prospective study looking at intraperitoneal cytology was conducted by using 400 consecutive radical hysterectomies from January 1988 through June 1996. All selected patients had peritoneal washings performed prior to a radical hysterectomy with pelvic and para-aortic lymphadenectomy. A single pathologist reviewed all cytological and histologic specimens. A total of 400 patients were included in the study. Only 7 of 400 (1.8%) had positive intraperitoneal cytology. Four had squamous cell cancer and 3 had adenocarcinoma. Five had stage IB cervical cancer and the remainder were stage IIA. Three had positive nodes. Six of 7 had tumor size greater than 3 cm. Three of 7 had > 50% invasion and 2 of 7 had lymphovascular space invasion. No other risk factors were present in these specimens. Six of 7 recurred within 18 months of surgery. Recurrences were local or retroperitoneal; none were upper abdomen or intraperitoneal. The incidence of positive peritoneal cytology during radical hysterectomy is 1.8%. The cost of these cytology specimens did not offer an advantage to the current surgical-pathological factors used to determine prognosis and adjuvant therapy.