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TERTIARY HYPERPARATHYROIDISM AFTER LONG-TERM PHOSPHATE SUPPLEMENTATION IN ADULT-ONSET HYPOPHOSPHATAEMIC OSTEOMALACIA

1996; Oxford University Press; Volume: 35; Issue: 6 Linguagem: Inglês

10.1093/rheumatology/35.6.598

1462-0332

J. NARVNoEZ, Jesús Rodríguez, C. Moragues, Ester Campoy, Teresa Clavaguera, D Roig-Escofet,

Alkaline Phosphatase Research Studies

We report the development of tertiary hyperparathyroidism in a patient with a sporadic form of adult-onset hypophosphataemic osteomalacia who had been treated with vitamin D or calcitriol and large doses of phosphate. This observation suggests that even with concomitant vitamin D or calcitriol therapy, long-term oral phosphate supplementation may lead to the development of hypercaicaemic hyperparathyroidism. Caution is recommended when relatively large doses of phosphate are used to treat hypophosphataemic osteomalacia of diverse causes.