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BIBTEX RIS

Anticancer and antimicrobial glycosides from ipomoea bahiensis

1986; Elsevier BV; Volume: 25; Issue: 5 Linguagem: Inglês

10.1016/s0031-9422(00)81557-5

1873-3700

Lothar W. Bieber, Ávaro Alves Da Silva Filho, Rosália M.O. Corrêa de Lima, Alda de Andrade Chiappeta, Silène Carneiro do Nascimento, Ivone Antônia de Souza, JOSE FRANCISCO DE MELLO, H. J. Veith,

Bioactive Compounds and Antitumor Agents

Four new antimicrobial glycosides have been isolated from Ipomoea bahiensis. Spectroscopic properties and basic and acidic hydrolysis characterized them as derivatives of 11 -hydroxy hexadecanoic and 11-hydroxy tetradecanoic acid, glycosidically linked in the 11-position to a trisaccharide unit composed of glucose, rhamnose and fucose which is esterified by tiglic and 3-hydroxy-2-methylbutyric acid. One of these compounds revealed significant activity against Sarcoma 180 in mice.